Insulin-mimetic vanadium compounds

COST D21/009/01


3rd Working-group meeting


6 and 7 September, 2004

Venue: Department of Inorganic and Analytical Chemistry, University of Szeged, Hungary


Local Organiser: Tamás Kiss, University of Szeged

Coordinator: Dieter Rehder, University of Hamburg, Germany


The WG meeting follows the 4th International Symposium on the Chemistry and Biological Chemistry of Vanadium, 3-5 September 2004, in Szeged (the 4th vanadium symposium in turn follows EUROBIC7, 29 August to 2 September 2004 in Garmisch-Partenkirchen, Germany)



Provisional programme of the WG meeting


Monday, 6 September 2004


9:00 T. Kiss, D. Rehder: Introductory remarks


9:30 I. Correia, I. Tomas, J. Costa Pessoa, T. Jakusch, T. Kiss, C. F.G.C. Geraldes, M.M.C.A. Castro: Multinuclear NMR solution characterisation of new vanadium(V) complexes with Schiff bases and reduced Schiff bases.


10:10 A. Salifoglou: Synthetic and mechanistic aspects of aqueous vanadium(IV,V) chemistry in the presence of physiological ligands

10:50 Coffee break

11:10 L. Pettersson: Speciation in the aqueous vanadate-citrate and peroxovanadate-citrate systems.

11:50 T. Kiss, Á. Dörnyei: VO(IV) binding abilities of saccharic acid and mucic acid

12:30 Lunch

14:30 P. Buglyó: Interactions of vanadium(III) with small molecules of potential biological importance

15:10 B. Meier: to be announced

15:50 I. Correia, J. Costa Pessoa, F. Avecilla: Structural studies of decavanadate compounds with protonated organic molecules and inorganic ions in their crystal packing

16:20 Coffee brake


16:40 D. Rehder, J. Gätjens, T. Kiss, P. Buglyó, H. Sakurai, B. Meier: A new family of insulin-mimetic vanadium compounds derived from 5-carboalkoxypicolinates.

17:20 J. Costa Pessoa: New potentially insulin-mimetic Schiff base vanadium complexes

18:00 General discussion

Dinner


Tuesday, 7 September 2004


8:30. M. Aureliano, A. Sousa, T. Tiago, L. Leonardo, A. Moderno, D. Tiago, S. Soares and A. Salifoglou: Vanadium complexes interactions with sarcoplasmic reticulum calcium pump

9:10. T. Tiago, P. Martel, C. Gutiérrez-Merino, J.J.G. Moura and M. Aureliano: A structural model for the decavanadate-myosin interaction at the phosphate-binding loop

9:40 Coffee break

10:10 E. Garriba, D. Sanna, G. Micera, K. Hegetschweiler, B. Morgenstern and S. Steinhauser: New Ligands for non-oxo vanadium(IV) complexes

10:40 T. Kabanos: Mononuclear vanadium compounds containing the cis-VO(OH) fragment

11:20 A. Gorzsás: On the fate of vanadate in human blood

12:00 Further projections and concluding remarks


List of Participants


Total number of participants 33


WG members for whom financial support is sought from COST


(Leaders of wg groups underlined)


Carlos GERALDES, University of Coimbra, Portugal

Margarina CASTRO, University of Coimbra, Portugal

João COSTA PESSOA, University of Lisbon, Portugal

Manuel AURELIANO, University of Lisbon, Portugal

Thanos SALIFOGLOU, Aristotle University of Thessaloniki, Greece

Maria KALYVA, Aristotle University of Thessaloniki, Greece

Themis KABANOS, University of Ioannina, Greece

Eugenio GARRIBA, University of Sassari, Italy

Daniele SANNA, University of Sassari, Italy

Lage PETTERSSON, University of Umeå, Sweden

Ingegärd ANDERSSON, University of Umeå, Sweden

András GORZSÁS, University of Umeå, Sweden

Fernando AVECILLA, University of Coruña, Spain

Beate MEIER, bcm research Entrischenbrunn, Germany

Dieter REHDER, University of Hamburg, Germany

Jessica GÄTJENS, University of Hamburg, Germany



No request for financial support


University of Szeged: Tamás Kiss, Tamás Gajda, Béla Gyurcsik, Pál Sipos, Melinda Kilyen, Krisztina Schrantz, Andrea Lakatos, Imre Labádi, Istvan Szilágyi, Dominik Hollender, Noémi Jakab, Ágnes Dörnyei, Tamás Jakusch

University of Debrecen: Péter Buglyó, Eszter Nagy,

University of Coimbra: Teresa Delgado

University of Lisbon: Teresa Tiago

University of Hamburg: Martin Ebel