frank@chem.u-szeged.hu
  • Dr. Éva Frank

    Dr. Éva Frank

    Department of Molecular and Analytical Chemistry

    University of Szeged

    Dóm tér 7-8., H-6720 Szeged, Hungary

    E-mail: frank@chem.u-szeged.hu

    Telephone: +36 62 544 275

    Curriculum Vitae

  • Curriculum Vitae

    Personal informations:

    Date of birth:

    Place of birth:

    Family:

     

    April 1, 1971

    Szeged, Hungary

    1 child ( Krisztián, 20.10.2002 )

    Educations:

    Chemistry, MSc. 1990-1995, József Attila University, Szeged, Hungary

    Pharmacy, MSc. 1996-2001, University of Szeged, Szeged, Hungary

    Ph.D (chemistry), 2000, University of Szeged, Hungary

    Dr. habil (chemistry), 2012, University of Szeged, Hungary

    Chemistry, DSc. 2018, Hungarian Academy of Sciences, Hungary

    Work experience:

    2017-

    2005-2017

    2001-2005

    1996-2000

    1997

     

    Associate professor, Department of Molecular and Analytical Chemistry, Szeged, Hungary

    Assistant professor, Department of Organic Chemistry, Szeged, Hungary

    Research fellow, Department of Organic Chemistry, Szeged, Hungary

    PhD student, Department of Organic Chemistry of József Attila University, Szeged, Hungary

    Visiting researcher (Institut für Organische Chemie der Georg-August Universität, Göttingen, Germany)

    Teaching experience:

    Organic Chemistry : laboratory practices for undergraduate students in biology, pharmacy and chemistry

    Organic Chemistry in Drug Research: lecture for students in chemistry and clinical chemistry

    Introductions to Medicinal Chemistry: lecture for undergraduates and postgraduates

    Organic Chemistry: lecture for undergraduate students

    Membership and role in scientific societies:

    Member of the Public Chamber of HAS (ID: 12517) (2003)

    Secretary of the Regional Committee of Szeged, Organic and Medicinal Chemistry Division of HAS (2006-2017)

    Secretary of the Working Committee on Steroid and Terpenoid Chemistry of HAS (2015-)

    Board member of the Organic- and Pharmaceutical Chemistry Division of HCS (2022-)

    Member of the International Relations Committee of HCS, Correspondent of the HCS in EuChemS Newsletter (2019-2024)

    Member of the Supervisory Board of Foundation for the Support of Young Chemists in Szeged (2014-)

    Editorial Board Member of Steroids (Elsevier) (2015-2019)

    Member of the Topical Advisory Panel of Molecules (MDPI) (2020-)

    Core member of the Doctoral School of Chemistry of USZ (2024-)

    Leader of the Organic Chemistry Program (2025-)

    Languages:

    English

    German ( written, read )

    Awards:

    Scientific Award of the Faculty of Science and Informatics ( 2015 )

    Bolyai János Research Fellowship ( 2007-2010 )

    Zemplén Géza Award ( 2007 )

    Békésy György Postdoctoral Fellowship ( 2004-2007 )

     

    Reasearch Interest

  • Research Interest

    •    Synthesis / structural analysis of bioactive organic compounds
    •    Preparation / structural modification of heterocyclic sterane-based derivatives
    •    Investigation of the mechanism and stereochemistry of organic reactions on steroid model compounds
    •    Synthesis of surfactants from natural feedstock

     

  • Education activities

    Lectures:

    2023-

    2021

    2012-2022

    2011-


    2006-2010

     

    ″Organic chemistry″ (Chemistry BSc, Chemical Engineering BSc)

    ″Chemistry of heterocyclic comounds″ (Chemistry BSc, distance)

    ″Organic chemistry″ (Bioengineering BSc)

    ″Fundamentals of pharmaceutical chemistry″ (Chemistry and Info-Bionics Engineering MSc) – (also in English)

    ″Organic chemistry of drug discovery ″ (Chemistry MSc)

    Practices:

    2011-2014


    2004-



    1995-1998

     

    ″Fundamentals of pharmaceutical chemistry″ (Chemistry and Info-Bionics Engineering MSc)

    Organic chemistry laboratory practices (undivided: Chemistry, Pharmacy and Chemistry Teachers, BSc: Chemistry, Biology, Bioengineering, Molecular Bionics and Materials Engineering)

    Supervising laboratory practices in organic chemistry as a PhD student

    Teaching abroad:

    2016

     

    Bioactive substance research (lecture and laboratory practices in English) – summer school (for BSc, MSc and PhD students)
    University of Tromsø - The Arctic University of Norway

    Educational development activity:

     

    Development of topics and educational aids (Organic chemistry - lecture and practice, Fundamentals of pharmaceutical chemistry - lecture – in Hungarian and English, Chemistry of heterocyclic compounds - lecture)
    Compiling a university textbook as a co-author (Frank É., Wölfling J. - Organic reaction mechanisms, JATEPress 2006, Szeged)

  • Contacts

    Dóm tér 7-8., H-6720
    Szeged, Hungary
    Tel.:+3662-544275
    E-mail: frank@chem.u-szeged.hu

  • Selected publications

    1. Frank É., Wölfling J., Aukszi B., König V., Schneider T. R., Schneider Gy.
      Stereoselective synthesis of some novel heterocyclic estrone derivatives by intramolecular 1,3-dipolar cycloaddition Link
      TETRAHEDRON 58: 6843-6849. (2002)
      IF: 2,420 (D1); DOI: 10.1016/S0040-4020(02)00741-X
    2. Frank É., Mucsi Z., Zupkó I., Réthy B., Falkay Gy., Schneider Gy., Wölfling, J.
      Efficient approach to androstene-fused arylpyrazolines as potent antiproliferative agents. Experimental and theoretical studies of substituent effects on BF3-catalyzed intramolecular [3+2]cycloadditions of olefinic phenylhydrazones Link
      JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 131: 3894-3904. (2009)
      IF: 8,580 (D1); DOI: 10.1021/ja808636e
    3. Kádár Z., Molnár J., Schneider Gy., Zupkó I., Frank É.
      A facile ″click″ approach to novel 15β-triazolyl-5alpha-androstane derivatives, and an evaluation of their antiproliferative activities in vitro Link
      BIOORGANIC & MEDICINAL CHEMISTRY 20: 1396-1402. (2012)
      IF: 2,903 (D1); DOI: 10.1016/j.bmc.2012.01.008
    4. Kovács D., Wölfling J., Szabó N., Szécsi M., Minorics R., Zupkó I., Frank, É.
      Efficient access to novel androsteno-17-(1′,3′,4′)-oxadiazoles and 17β-(1′,3′,4′)-thiadiazoles via N-substituted hydrazone and N,N′-disubstituted hydrazine intermediates, and their pharmacological evaluation in vitro Link
      EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 98: 13-29. (2015)
      IF: 3,902 (Q1); DOI: 10.1016/j.ejmech.2015.05.010
    5. Baji Á., Gyovai A., Wölfling J., Minorics R., Ocsovszki I., Zupkó I., Frank É.
      Microwave-assisted one-pot synthesis of steroid–quinoline hybrids and an evaluation of their antiproliferative activities on gynecological cancer cell lines Link
      RSC ADVANCES 6: 27501-27516. (2016)
      IF: 3,108 (Q1); DOI: 10.1039/C6RA03910C
    6. Petrasheuskaya T. V, Kiss M. A., Dömötör O., Holczbauer T., May N. V., Spengler G., Kincses A., Čipak Gašparović A., Frank É., Enyedy É. A.
      Salicylaldehyde thiosemicarbazone copper complexes: impact of hybridization with estrone on cytotoxicity, solution stability and redox activity Link
      NEW JOURNAL OF CHEMISTRY 44: 12154-12168. (2020)
      IF: 3,591 (Q1); DOI: 10.1039/d0nj01070g
    7. Kovács F., Gopisetty M. K., Adamecz D. I., Kiricsi M., Enyedy É. A., Frank É.
      Synthesis and conversion of primary and secondary 2-aminoestradiols into A-ring-integrated benzoxazolone hybrids and their in vitro anticancer activity Link
      RSC ADVANCES 11: 13885, 2021, 12 p. (2021)
      IF: 4,036 (Q1); DOI: 10.1039/d1ra01889b
    8. Kiss M. A., Peřina M., Bazgier V., May N. V., Baji Á., Jorda R., Frank, É.
      Synthesis of dihydrotestosterone derivatives modified in the A-ring with (hetero) arylidene, pyrazolo[1,5-α]pyrimidine and triazolo[1,5-α]pyrimidine moieties and their targeting of the androgen receptor in prostate cancer Link
      JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 211:105904 (2021)
      IF: 5,011 (Q1); DOI: 10.1016/j.jsbmb.2021.105904
    9. Kovács F., Adamecz D., Nagy F. I., Papp B., Kiricsi M., Frank É.
      Substitutional diversity-oriented synthesis and in vitro anticancer activity of framework-integrated estradiol-benzisoxazole chimeras Link
      MOLECULES 27: 7456 (2022)
      IF: 4,6 (Q1); DOI: 10.3390/molecules27217456
    10. Peřina M., Kiss M. A., Mótyán G., Szczyrbová E., Eliáš M., Študent jr V., Kurfurstov, D., Kovalová M., Mada L., Bouchal J., Frank É., Jorda R.
      A-ring-fused pyrazoles of dihydrotestosterone targeting prostate cancer cells via the downregulation of the androgen receptor Link
      EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 249: 115086 (2023)
      IF: 6,0 (D1); DOI: 10.1016/j.ejmech.2023.115086 
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